molecular basis of breast cancer ppt

Direct multiplexed measurement of gene expression with color-coded probe pairs. The ACCC survey finds the most standardization for breast cancer biomarker testing and wide variability in testing for lung, colorectal, and leukemia. x�b```f``Y������� �� @16�wB�ħ. Metastases are the principal cause of death in patients with cancer. 3). 0000004383 00000 n Nature Biotech. 0000001569 00000 n 0000025972 00000 n The steroid hormone receptors in the breast epithelium, and finally the importance of full differentiation as a discoveries of the association of hereditary breast cancers with mutations in the BRCAl and BRCA2 tool for protecting the breast from developing cancer. 0000039424 00000 n 0000001116 00000 n 0000002071 00000 n Presenter Dr Dhanya A N See our User Agreement and Privacy Policy. Avg rating: 3.0/5.0. 0000034838 00000 n The bethesda system for reporting thyroid cytopathology, Customer Code: Creating a Company Customers Love, Be A Great Product Leader (Amplify, Oct 2019), No public clipboards found for this slide, JSS University (Jagadguru Sri Shivarathreeshwara University),Mysore. ER status has been shown to be the major determinant of breast cancer molecular portraits by recent gene expression profiling (GEP) studies [17-21]. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The ESMO Clinical Practice Guidelines (CPG) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings of evidence-based … 0000038548 00000 n Molecular Basis of Aging and Breast Cancer. Molecular basis of Cancer 1. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. %PDF-1.4 %���� 0000033205 00000 n 0000022662 00000 n 0000033731 00000 n •AR is the most commonly expressed hormone receptor in breast cancer •Up to 90% of breast cancers are positive depending upon methods and cut offs used (literature 60-90%) •ER + - 85-95% AR+ (LumA –91%, LumB –68%) •ER - - 15-70% AR+ depending on series •ER-/ HER2+ - 50-66% AR+ •TNBC –32% AR+ (20-55%) Apocrine Carcinoma and AR Molecular subtyping of triple‐negative breast cancers (TNBCs) via gene expression profiling is essential for understanding the molecular essence of this heterogeneous disease and for guiding individualized treatment. Molecular markers over the last 10 years have amplified due to the increasing advancements made in understanding the molecular biology of cancer and also the molecular basis of tumor progression and treatment response. Breast cancer is the most common cancer in women, with a lifetime risk of 12% (one in eight) for average-risk women (1,2), and is the second most common cause of death from cancer in women.Mortality rates after a diagnosis of breast cancer began to decrease in 1991 as a result of improvements in early detection and refined treatment options (3,4). Molecular Basis of Cancer - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. 0000031849 00000 n If you continue browsing the site, you agree to the use of cookies on this website. Slides: 43. Gluck S, de Snoo f, Peeters J et al. Clipping is a handy way to collect important slides you want to go back to later. patient with breast cancer will routinely have ER/PR/HER2 testing. If you continue browsing the site, you agree to the use of cookies on this website. 0000001911 00000 n 0000032878 00000 n 0000004417 00000 n The reason is that breast carcinomas are heterogeneous and vary greatly in physical appearance, or their phenotype, on both a macroscopic and molecular scale (see Chap. Another example, the retinoblastoma (RB) gene encodes for the protein Rb, which regulates the cell cycle by stopping DNA replication. The molecular basis of breast cancer prevention and treatment and other kinds of academic papers in our essays database at Many Essays. 0000021591 00000 n These genetic alterations involve activation of proto-oncogenes to oncogenes, deregulation of tumour suppressor genes and DNA repair genes and ‘immortalisation’ which will be discussed in this chapter. Targeted therapy works by interfering with a specific molecular target, though inter-individual variability in drug response often causes treatment failure. 0000009307 00000 n Mutations in the RB gene family occur in many human cancers, allowing affected cells to divide continuously. molecular profiling of breast cancer dr dhanya a n sri siddhartha medical college, tumkur. 0000023735 00000 n It is a multi-step process that requires the accumulation of many genetic changes over time (Figure 1). 0000019376 00000 n Actions. MOLECULAR BASIS OF CANCER Nethravathi R GN113011 1 2. It is of interest that all of the parous women in our … 2013;133:929-936. While this seems fairly concise, breast cancer extends to a diverse group of maladies. 71–78 This concept recognizes that different subpopulations that have acquired additional genetic mutations compete with each other under selective pressure as cancers grow, progress, and metastasize. Although the breast tissues of parous women from the general population contain predominantly Lob 3 and a very low percentage of Lob 1, in those parous women who have developed breast cancer, their breast tissues have also the Lob 1 as the predominant structure, appearing in this sense similar to those of nulliparous women. José and Irma Russos' new book on the Molecular Basis of Breast Cancer: Prevention and Treatment tackles the problem by following a logical path of first introducing the disease from the epidemiological point of view, before discussing how the breast develops and becomes altered in cancer, and how we might seek to understand it through both in vivo and culture models. In non-small cell lung cancer (NSCLC), tissue samples may be limited and there may be more variability in the types of biomarkers that are ordered. 0000024278 00000 n It is frequently treated with chemotherapy and hormone therapy. 0000035447 00000 n Introduction. The molecular basis of breast cancer phenotypes was initially investigated using loss of heterozygosity analysis (LOH), which can indicate tumour suppressor gene inactivation. The integration of morphological with molecular data has the potential to refine breast cancer classification, predict response to therapy, enhance our understanding of breast cancer biology, and improve clinical management. 0000018404 00000 n 2. Int J Cancer. The Molecular Basis of Cancer consists of contributionsfrom an accomplished array of molecular biologists and immunologists.The editors' aim, as stated in the preface, is "...to explain,rather than merely recount, the discoveries and observations thatform the basis for understanding a disease...." 0000004012 00000 n Elucidation of the cellular and molecular mechanism by which breast cancer selectively spreads to bone is essential for the development of mechanism-based effective and specific therapeutic interventions for this deleterious complication in breast cancer. genetic analysis of breast cancer is not easily available in clinical practice due to its high cost and the extensive resources required, surrogate definitions of the subtype based on semiquantitative IHC scoring of ER, PR, and in situ hybridization tests for HER2 overexpression have been proposed (Table 1) [5]. Molecular Basis of Cancer - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. Remove this ... Lecture: 1 Molecular Basis of Cancer PSA Test for Prostate Cancer Tumor cells express abnormal genes so form abnormal proteins ... – PowerPoint PPT presentation . Breast Cancer Treatment - Molecular and Cellular Basis. 0000032599 00000 n Lastly, recent evidence highlighting the molecular and genetic heterogeneity of cancers (including breast) has brought to the forefront the concept of clonal evolution in cancer. • Molecular testing in breast cancer is used to – Classify tumor types, – recognize hereditary implications (eg, BRCA1 mutations) – identify appropriate therapeutic agents (eg, HER2+ disease or ER/PR + disease), – determine the prognosis of the disease by giving the risk score, – identify biomarkers that can predict or monitor the response to treatment – To avoid unnecessary treatment to all cancer … The name of “breast cancer” is the general term for carcinomas of the breast tissue. Immunohistochemistry based molecular subtyping of tumors is now considered as the main … trailer <]>> startxref 0 %%EOF 74 0 obj<>stream Prognostic markers evaluate the … Cancer is a disease of uncontrolled growth and proliferation whereby cells have escaped the body’s normal growth control mechanisms and have gained the ability to divide indefinitely. 0000034018 00000 n This study aimed to comprehensively elucidate the molecular basis of breast cancer morphological phenotypes by integrating genomic, transcriptomic and proteomic data with morphological features, and to determine whether morphology transcriptomic signatures were prognostic in ER-positive or ER-negative breast cancer. , though inter-individual variability in testing for lung, colorectal, and to you. A prospective evaluation of a breast cancer will routinely have ER/PR/HER2 testing and routinely determined by a technique. 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